A structured educational intervention significantly reduced olanzapine-induced weight gain compared to standard care (-0.06 pounds vs 9.57 pounds at 6 months).
RCT (n=70)
Does a structured educational intervention reduce antipsychotic-induced weight gain in patients with schizophrenia starting olanzapine?
A structured educational intervention significantly mitigated olanzapine-induced weight gain in patients with schizophrenia.
Absolute Event Rate: -0.06% vs 9.57%
PURPOSE: To assess the effect of an educational intervention on antipsychotic-induced weight gain among patients with schizophrenia. DESIGN AND METHODS: Quasi-experimental. Seventy patients with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder entered this 6-month study condicted in the United States. All participants began receiving olanzapine treatment when they entered the study. The patients were then randomly assigned to an intervention group or a standard care group. Over the next 4-months, the intervention group participated in weekly psychoeducation classes focused on nutrition, exercise, and living a healthy lifestyle. Patients were followed for an additional 2 months to assess weight change. FINDINGS: A statistically significant difference in weight change between the two groups was observed post-treatment and at endpoint. At endpoint, the mean weight change of the intervention group was -.06 pounds, while the mean weight change in the standard care group was 9.57 pounds. In both groups, men gained significantly more weight than did women. CONCLUSIONS: The results indicate that a structured educational intervention might have a positive effect on antipsychotic-induced weight gain among patients with schizophrenia.
Littrell et al. (2003) conducted an RCT in Schizophrenia or schizoaffective disorder (n=70). Structured educational intervention (psychoeducation classes) vs. Standard care was evaluated on Weight change at endpoint. A structured educational intervention significantly reduced olanzapine-induced weight gain compared to standard care (-0.06 pounds vs 9.57 pounds at 6 months).