Weight Gain and Metabolic Changes in Patients With First-Episode Psychosis or Early-Phase Schizophrenia Treated With Olanzapine: A Meta-Analysis
Key result
Olanzapine treatment in first-episode psychosis or early-phase schizophrenia was associated with a mean weight gain of 7.53 kg (95% CI 6.42-8.63), which was greater in studies lasting >13 weeks.
Why the study?
Patients with first-episode psychosis or early-phase schizophrenia are susceptible to olanzapine-associated weight gain and cardiometabolic dysregulation.
Does olanzapine treatment cause weight gain and metabolic changes in patients with first-episode psychosis or early-phase schizophrenia?
Population
Patients with first-episode psychosis or early-phase schizophrenia across 26 RCTs
Comparison
Olanzapine treatment
Design
Meta-analysis of randomized controlled trials
Authors
Discussion
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Implication
Clinicians should prioritize metabolic monitoring or alternatives with olanzapine in first-episode psychosis; confirms clinically meaningful weight gain (~7.5 kg) in this population.
Study Design
Type
Meta-Analysis
Structured PICO
Does olanzapine treatment cause weight gain and metabolic changes in patients with first-episode psychosis or early-phase schizophrenia?
P
Population
Meta-analysis of 26 RCTs evaluating weight and metabolic effects of olanzapine treatment in patients with first-episode psychosis or early-phase schizophrenia.
I
Intervention
Olanzapine treatment
O
Outcome
Weight gain and cardiometabolic outcomessafety
Main Result
Mean Difference: 7.53 (95% CI 6.42–8.63)
Olanzapine treatment in first-episode psychosis or early-phase schizophrenia is consistently associated with significant weight gain, which increases with longer treatment duration.
Limitations
- RCTs may underestimate metabolic sequelae vs real-world treatment observations.
- RCTs may underestimate metabolic sequelae vs real-world treatment observations
Cite This Study
Correll et al. (2023) conducted a meta-analysis in First-episode psychosis or early-phase schizophrenia. Olanzapine was evaluated on Weight gain (Mean weight gain 7.53 kg, 95% CI 6.42-8.63). Olanzapine treatment in first-episode psychosis or early-phase schizophrenia was associated with a mean weight gain of 7.53 kg (95% CI 6.42-8.63), which was greater in studies lasting >13 weeks.