What question did this study set out to answer?

To assess the effects of the antipsychotic olanzapine on body weight, body mass index, and waist circumference in adults, while evaluating time- and dose–response relationships.

September 18, 2026Scottish Medical Journal

Impact of olanzapine on body weight, body mass index, and waist circumference: A time- and dose–response meta-analysis of randomized controlled trials

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Authors

AAAhmed Abu‐Zaid RAReem Alyoubi HAHuda Yahya Alyahyawi

Discussion

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Overview

Meta-analysis of randomized controlled trials reveals significant increases in weight and waist circumference with olanzapine in adults, highlighting the need for metabolic monitoring.

Key Points

To assess the effects of the antipsychotic olanzapine on body weight, body mass index, and waist circumference in adults, while evaluating time- and dose–response relationships.
Systematic search of PubMed, Embase, Scopus, and Web of Science through June 2025 for randomized controlled trials comparing olanzapine with placebo in adults.
Meta-analyzed 15 randomized controlled trials comprising 18 study arms reporting baseline and follow-up anthropometric data using random-effects models.
Olanzapine significantly increased body weight (16 arms; WMD: 1.72 kg; 95% CI: 0.55–2.88; p = 0.004), BMI (4 arms; WMD: 0.84 kg/m²; 95% CI: 0.24–1.43; p = 0.005), and waist circumference (2 arms; WMD: 5.79 cm; 95% CI: 1.85–9.73; p = 0.004) compared with placebo.
Pronounced weight increases occurred at doses ≥10 mg/day, during the first 12 weeks of treatment, and in participants with a baseline BMI <25 kg/m², with dose–response analyses showing increased gain above 5 mg/day.

Cite This Study

Abu‐Zaid et al. (2026) studied this question.

synapsesocial.com/papers/6aad0bb6de0393d728b8a281 https://doi.org/10.1177/00369330261487638

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September 18, 2026Scottish Medical Journal

Impact of olanzapine on body weight, body mass index, and waist circumference: A time- and dose–response meta-analysis of randomized controlled trials

View Full Paper

Ask AI

Bookmark

Authors

AAAhmed Abu‐Zaid RAReem Alyoubi HAHuda Yahya Alyahyawi

Discussion

Member takes

Overview

Meta-analysis of randomized controlled trials reveals significant increases in weight and waist circumference with olanzapine in adults, highlighting the need for metabolic monitoring.

Key Points

To assess the effects of the antipsychotic olanzapine on body weight, body mass index, and waist circumference in adults, while evaluating time- and dose–response relationships.
Systematic search of PubMed, Embase, Scopus, and Web of Science through June 2025 for randomized controlled trials comparing olanzapine with placebo in adults.
Meta-analyzed 15 randomized controlled trials comprising 18 study arms reporting baseline and follow-up anthropometric data using random-effects models.
Olanzapine significantly increased body weight (16 arms; WMD: 1.72 kg; 95% CI: 0.55–2.88; p = 0.004), BMI (4 arms; WMD: 0.84 kg/m²; 95% CI: 0.24–1.43; p = 0.005), and waist circumference (2 arms; WMD: 5.79 cm; 95% CI: 1.85–9.73; p = 0.004) compared with placebo.
Pronounced weight increases occurred at doses ≥10 mg/day, during the first 12 weeks of treatment, and in participants with a baseline BMI <25 kg/m², with dose–response analyses showing increased gain above 5 mg/day.

Cite This Study

Abu‐Zaid et al. (2026) studied this question.

synapsesocial.com/papers/6aad0bb6de0393d728b8a281 https://doi.org/10.1177/00369330261487638

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