Key result
Arrhythmias reduce simulated coronary blood flow by up to ~28% versus healthy cases.
Why the study?
Hydrodynamical models are rarely used to study the effects of arrhythmias on coronary blood flow.
Do arrhythmias and asynchronous pacing reduce coronary blood flow in a computational model?
Do arrhythmias and asynchronous pacing reduce coronary blood flow in a computational model?
A 1D mathematical model demonstrates that arrhythmias such as long QT syndrome and premature ventricular contractions significantly decrease coronary blood flow compared to a healthy state.
Answers are grounded in this paper and cite their sources.
May impair coronary perfusion during arrhythmias in models; hypothesis-generating and leaves open clinical relevance.
In this work we present a one-dimensional (1D) mathematical model of the coronary circulation and use it to study the effects of arrhythmias on coronary blood flow (CBF). Hydrodynamical models are rarely used to study arrhythmias’ effects on CBF. Our model accounts for action potential duration, which updates the length of systole depending on the heart rate. It also includes dependency of stroke volume on heart rate, which is based on clinical data. We apply the new methodology to the computational evaluation of CBF during interventricular asynchrony due to cardiac pacing and some types of arrhythmias including tachycardia, bradycardia, long QT syndrome and premature ventricular contraction (bigeminy, trigeminy, quadrigeminy). We find that CBF can be significantly affected by arrhythmias. CBF at rest (60 bpm) is 26% lower in LCA and 22% lower in RCA for long QT syndrome. During bigeminy, trigeminy and quadrigeminy, respectively, CBF decreases by 28%, 19% and 14% with respect to a healthy case.
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Гамилов et al. (2020) studied Arrhythmias. Arrhythmias (long QT syndrome, premature ventricular contraction) vs. Healthy case was evaluated on Coronary blood flow (CBF). Arrhythmias significantly reduced simulated coronary blood flow, with decreases of 26% in the left coronary artery for long QT syndrome and 28% during bigeminy compared to a healthy case.
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