Key result
Multiscale 0D-1D computational models demonstrate that cardiac arrhythmias, particularly atrial fibrillation, significantly impair coronary hemodynamics, with perfusion worsening as heart rate increases.
Why the study?
The effects of cardiac arrhythmias on the coronary circulation remain poorly understood, prompting a review of state-of-the-art 0D-1D multiscale computational models of the arterial coronary system.
Does 0D-1D computational modeling reveal hemodynamic alterations in coronary circulation induced by cardiac arrhythmias?
Does 0D-1D computational modeling reveal hemodynamic alterations in coronary circulation induced by cardiac arrhythmias?
0D-1D computational models demonstrate that cardiac arrhythmias, particularly at higher heart rates, significantly impair coronary hemodynamics and perfusion.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for arrhythmia effects on coronary perfusion; leaves open prospective clinical validation before any practice implications.
Computational hemodynamics is becoming an increasingly important tool in clinical applications and surgical procedures involving the cardiovascular system. Aim of this review is to provide a compact summary of state of the art 0D-1D multiscale models of the arterial coronary system, with particular attention to applications related to cardiac arrhythmias, whose effects on the coronary circulation remain so far poorly understood. The focus on 0D-1D models only is motivated by the competitive computational cost, the reliability of the outcomes for the whole cardiovascular system, and the ability to directly account for cardiac arrhythmias. The analyzed studies show that cardiac arrhythmias by their own are able to promote significant alterations of the coronary hemodynamics, with a worse scenario as the mean heart rate (HR) increases. The present review can stimulate future investigation, both in computational and clinical research, devoted to the hemodynamic effects induced by cardiac arrhythmias on the coronary circulation.
No takes yet. Share an insight, caveat, or question.
Scarsoglio et al. (2021) conducted a review in Cardiac arrhythmias and coronary circulation. 0D-1D computational modeling was evaluated. Multiscale 0D-1D computational models demonstrate that cardiac arrhythmias, particularly atrial fibrillation, significantly impair coronary hemodynamics, with perfusion worsening as heart rate increases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: