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January 1, 2013Computational and Mathematical Methods in MedicineOpen Access

Towards Patient-Specific Modeling of Coronary Hemodynamics in Healthy and Diseased State

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Key result

A coupled microstructure-based heart contraction and 1D wave propagation model qualitatively predicted coronary hemodynamics in healthy and diseased states based on patient-specific data.

Population

Computational model of coronary hemodynamics simulating healthy state, coronary epicardial stenoses, and…

Design

Other

Authors

AHArjen van der HorstFBFrits L. BoogaardMVMarcel van’t Veer

Discussion

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Overview

May support patient-specific coronary flow simulation; leaves open prospective validation before any clinical use.

Structured PICO

P
Population
Computational model of coronary hemodynamics simulating healthy state, coronary epicardial stenoses, and left ventricular hypertrophy with aortic valve stenosis
I
Intervention
Coupling of a microstructure-based heart contraction model with a 1D wave propagation model
O
Outcome
Dynamics of pressure and flow compared to literature observations

A coupled computational model of heart contraction and 1D wave propagation can adequately predict coronary hemodynamics in normal and diseased states.

Cite This Study

Horst et al. (2013) studied Coronary circulatory disease. Coupled microstructure-based heart contraction and 1D wave propagation model was evaluated on Dynamics of pressure and flow. A coupled microstructure-based heart contraction and 1D wave propagation model qualitatively predicted coronary hemodynamics in healthy and diseased states based on patient-specific data.

synapsesocial.com/papers/6a93cb525dfd4fc6b4b99fe5https://doi.org/10.1155/2013/393792
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