What does this research mean for the field?

Carvedilol reversibly inhibits vascular smooth muscle cell proliferation induced by various mitogens, an antiproliferative effect that is not broadly shared by other beta-adrenoceptor antagonists. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research evaluates the antiproliferative effects of carvedilol on vascular smooth muscle cells.

February 1, 1993Journal of Cardiovascular Pharmacology

Carvedilol Inhibits Vascular Smooth Muscle Cell Proliferation

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Why the study?

Does carvedilol inhibit mitogenesis in cultured rat aortic vascular smooth muscle cells?

Key Points

This research evaluates the antiproliferative effects of carvedilol on vascular smooth muscle cells.
In vitro study using early passage cultured rat aortic vascular smooth muscle cells.
Assessment of the effects of carvedilol at various concentrations on cell proliferation and thymidine incorporation.
Comparisons made with other beta-adrenoceptor antagonists and a calcium channel antagonist.
Carvedilol (10 microM) reduced basal mitogenesis by approximately 65% and endothelin-1-stimulated mitogenesis by approximately 95%.
The IC50 for inhibition of thymidine incorporation was about 1 microM.
Inhibition of cell proliferation by carvedilol was concentration-dependent and reversible.

Structured PICO

Does carvedilol inhibit mitogenesis in cultured rat aortic vascular smooth muscle cells?

Population

Early passage cultured rat aortic vascular smooth muscle cells

Intervention

Carvedilol (10(-7)-10(-5) M)

Comparator

Basal conditions, other beta-adrenoceptor antagonists (labetalol, celiprolol, sotalol, propranolol), and calcium channel antagonist nifedipine

Outcome

Mitogenesis (measured by [3H]thymidine incorporation and cell number)surrogate

Carvedilol demonstrates significant, reversible antiproliferative effects on vascular smooth muscle cells, distinguishing it from most other beta-blockers.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support unique antiproliferative effects of carvedilol in VSMCs; leaves open clinical translation in humans.

Cite This Study

Sung et al. (1993) studied this question.

synapsesocial.com/papers/6a130ee286514ddae6c11188 https://doi.org/10.1097/00005344-199302000-00006

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Carvedilol Inhibits Vascular Smooth Muscle Cell Proliferation

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Carvedilol Inhibits Vascular Smooth Muscle Cell Proliferation

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider