August 26, 2015International Journal of Stroke
Heart Rate and Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke (Regards) Study
Key result
Each 10 bpm increase in resting heart rate was associated with a 10% increase in the risk of ischemic stroke (HR 1.10; 95% CI 1.02-1.18).
Why the study?
Does a higher resting heart rate increase the risk of first-time ischemic stroke in a stroke-free population?
Population
24,730 participants free of stroke at the time of enrollment, mean age 64 ± 9.3 years, 59% women, 41%…
Comparison
Higher resting heart rate. vs Lower resting heart rate (lower tertile <61 bpm).
Design
Cohort
Follow-up
median 7.6 years
Authors
Discussion
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Implication
May refine stroke risk stratification; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort (n=24,730)
Multicenter
Yes
Structured PICO
Does a higher resting heart rate increase the risk of first-time ischemic stroke in a stroke-free population?
P
Population
24,730 participants free of stroke at the time of enrollment, mean age 64 ± 9.3 years, 59% women, 41% blacks, from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
I
Intervention
Higher resting heart rate (evaluated continuously per 10 bpm increase, and categorically in middle [61 to 70 bpm] and upper [>70 bpm] tertiles).
C
Comparator
Lower resting heart rate (lower tertile <61 bpm).
O
Outcome
First-time ischemic stroke events adjudicated by physician review.hard clinical
Main Result
Effect estimate: HR 1.10 (95% CI 1.02-1.18)
Higher resting heart rate is independently associated with an increased risk of incident ischemic stroke in a stroke-free population.
Cite This Study
O’Neal et al. (2015) conducted a cohort in Ischemic stroke (n=24,730). Resting heart rate vs. Lower resting heart rate was evaluated on First-time ischemic stroke events (HR 1.10, 95% CI 1.02-1.18). Each 10 bpm increase in resting heart rate was associated with a 10% increase in the risk of ischemic stroke (HR 1.10; 95% CI 1.02-1.18).