Key result
A resting heart rate >82 b.p.m. after ischaemic stroke was associated with a higher risk of total death compared to the lowest quintile (HR 1.74; 95% CI 1.48-2.06; P<0.0001).
Why the study?
Does a higher resting heart rate increase the risk of mortality, disability, and cognitive decline in patients after ischaemic stroke?
Population
20,165 patients after ischaemic stroke (mean age 66.1, SD 8.6 years) from the PRoFESS trial
Comparison
Higher resting heart rate vs Lowest quintile of resting heart rate
Design
Cohort
Authors
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Identifies post-stroke heart rate as a mortality risk marker; hypothesis-generating for rate-control trials, should not change practice.
RCT (n=20,165)
Randomized
Does a higher resting heart rate increase the risk of mortality, disability, and cognitive decline in patients after ischaemic stroke?
Hazard Ratio: 1.74 (95% CI 1.48–2.06)
p-value: p=< 0.0001
In patients with prior ischemic stroke, a higher resting heart rate is associated with increased mortality, worse functional outcomes, and greater cognitive decline.
Böhm et al. (2012) conducted an RCT in Ischaemic stroke (n=20,165). High resting heart rate (>82 b.p.m.) vs. Lowest quintile of resting heart rate was evaluated on Total death (HR 1.74, 95% CI 1.48-2.06, p=< 0.0001). A resting heart rate >82 b.p.m. after ischaemic stroke was associated with a higher risk of total death compared to the lowest quintile (HR 1.74; 95% CI 1.48-2.06; P<0.0001).
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