What does this research mean for the field?

Left ventricular hypertrophy is significantly more pronounced in patients with primary aldosteronism than in patients with essential hypertension or other forms of secondary hypertension, despite similar blood pressure levels and disease duration. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1997Hypertension ResearchOpen Access

Left Ventricular Hypertrophy Is More Prominent in Patients with Primary Aldosteronism than in Patients with Other Types of Secondary Hypertension.

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Why the study?

Is left ventricular hypertrophy more prominent in patients with primary aldosteronism compared to other types of secondary and essential hypertension?

Population

138 subjects including 20 patients with primary aldosteronism, 12 with Cushing's syndrome, 9 with…

Design

Cross-sectional

Authors

ATAkiyo TanabeNational Center for Global Health and Medicine MNMitsuhide NarusePreventive Cardiology KNKiyoko NaruseAtlas Scientific (United States)

Discussion

Member takes

Implication

LVH severity may prompt primary aldosteronism evaluation; leaves open causal role of aldosterone and need for prospective therapy trials.

Structured PICO

Is left ventricular hypertrophy more prominent in patients with primary aldosteronism compared to other types of secondary and essential hypertension?

Population

138 subjects including 20 patients with primary aldosteronism, 12 with Cushing's syndrome, 9 with pheochromocytoma, 47 with essential hypertension, and 50 healthy normotensive subjects. Excluded: previous history of myocardial infarction, bundle branch block, long Q-T syndrome, arrhythmias, Q or Q-S patterns suggestive of infarction, or echocardiographic evidence of infiltrative or valvular heart disease.

Comparator

Normotensive subjects and patients with other forms of hypertension (Cushing's syndrome, pheochromocytoma, and essential hypertension)

Outcome

Left ventricular mass index (LVMI)surrogate

Patients with primary aldosteronism exhibit significantly more pronounced left ventricular hypertrophy than those with other forms of hypertension, suggesting aldosterone plays a key role in cardiac remodeling independent of blood pressure.

Limitations

Possible modification of cardiac structure and function by prior antihypertensive treatment

Cite This Study

Tanabe et al. (1997) studied this question.

synapsesocial.com/papers/6a1349edae549d8bbc3c2369 https://doi.org/10.1291/hypres.20.85

Topics

Hypertension management Echocardiography

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Left Ventricular Hypertrophy Is More Prominent in Patients with Primary Aldosteronism than in Patients with Other Types of Secondary Hypertension.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Left Ventricular Hypertrophy Is More Prominent in Patients with Primary Aldosteronism than in Patients with Other Types of Secondary Hypertension.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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