Key result
aKD is linked to reduced LV longitudinal strain and global constructive work.
Why the study?
To evaluate subclinical LV systolic dysfunction in acute-phase Kawasaki disease patients using hematological indices, global layer-specific LV longitudinal strain, and myocardial work.
Can layer-specific LV longitudinal strain and global myocardial work detect subclinical LV systolic dysfunction in patients with acute-phase Kawasaki disease compared to normal controls?
Case-Control (n=85)
Can layer-specific LV longitudinal strain and global myocardial work detect subclinical LV systolic dysfunction in patients with acute-phase Kawasaki disease compared to normal controls?
Layer-specific longitudinal strain and myocardial work indices can effectively detect subclinical left ventricular systolic dysfunction in patients with acute-phase Kawasaki disease.
Answers are grounded in this paper and cite their sources.
May support subclinical LV dysfunction detection in acute KD; leaves open prospective validation before clinical use.
PURPOSE: To evaluate subclinical LV systolic dysfunction in aKD patients by hematological indices, global layer-specific LV longitudinal strain and myocardial work (MW). METHODS: Forty-three normal controls and 42 aKD patients were enrolled in the present study. The peak systolic epimyocardial (GLSEpi), middle layer (GLSMid) and endomyocardial (GLSEndo) longitudinal strain, global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW) and myocardial work efficiency (GWE) were measured by two-dimensional speckle-tracking echocardiography in apical three-chamber, four-chamber, and two-chamber views. RESULTS: The absolute values of GLSEpi, GLSMid, and GLSEndo in aKD patients were significantly lower than those in normal controls (p < .01). The values of GCW and GWE were significantly lower than those of normal controls (p < .05). There were no significant differences among the AUCs of layer-specific LV GLS and global MW (p > .05). The correlation test showed that layer-specific LV GLS showed a good correlation with GCW. Multivariable analysis showed that Hb and LVEF were independent factors for GCW. CONCLUSION: In this research, we found that subclinical LV systolic dysfunction was detected by layer-specific GLS and MW in aKD patients. GCW has the same diagnostic value as layer-specific LV GLS. Hb and LVEF are independent factors of LV myocardial function.
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Li et al. (2023) conducted a case-control in Acute-phase Kawasaki disease (n=85). Two-dimensional speckle-tracking echocardiography vs. Normal controls was evaluated on Subclinical LV systolic dysfunction (layer-specific LV longitudinal strain and myocardial work) (p=<.01). Two-dimensional speckle-tracking echocardiography revealed significantly lower absolute values of layer-specific LV longitudinal strain (p<0.01) and global constructive work (p<0.05) in aKD patients.
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