Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 27, 2015Iranian Journal of PediatricsOpen Access

Noninvasive Evaluation of Myocardial Systolic Dysfunction in the Early Stage of Kawasaki Disease: A Speckle-Tracking Echocardiography Study

View Full Paper
Ask AI
Bookmark
Share

Key result

Kawasaki Disease in the acute phase was associated with significantly reduced mean global strain (17.03% vs 20.22%) and strain rate (1.66 vs 1.97 1/s) compared to healthy controls.

Why the study?

Does speckle-tracking echocardiography detect early myocardial systolic dysfunction in patients with acute Kawasaki Disease compared to healthy controls?

Population

32 patients with Kawasaki Disease in the acute phase, 65.5% male, 75% younger than 4 years, and 19 healthy…

Comparison

Speckle-tracking echocardiography vs Healthy control subjects with normal…

Design

Case-control

Authors

MHMohammad-Nasir HematianSTShirin TorabiIslamic Azad University Central Tehran BranchERElaheh Malakan RadUniversity of Lahore

Discussion

Loading...

Member takes

Implication

Speckle-tracking may identify subclinical systolic dysfunction in acute Kawasaki disease; hypothesis-generating and needs prospective validation.

Study Design

Type

Case-Control (n=51)

Structured PICO

Does speckle-tracking echocardiography detect early myocardial systolic dysfunction in patients with acute Kawasaki Disease compared to healthy controls?

P
Population
32 patients with Kawasaki Disease (KD) in the acute phase (before intravenous immunoglobulin administration), 65.5% male, 75% younger than 4 years, and 19 healthy control subjects. Excluded: history of hypertension, diabetes, coronary artery disease, myocardial infarction, stroke, congenital heart disease, acquired valvular disease, dysrhythmia, or congestive heart failure.
I
Intervention
Speckle-tracking echocardiography (evaluation of Strain, Strain Rate, Time to Peak Strain, Time to Peak Strain Rate, longitudinal velocity, and view point velocity)
C
Comparator
Healthy control subjects with normal echocardiography
O
Outcome
Global Strain (S) and Strain Rate (SR)surrogate

Main Result

Absolute Event Rate: 17.03% vs 20.22%

p-value: p=<0.001

Speckle-tracking echocardiography reveals reduced global strain and strain rate in the acute phase of Kawasaki disease, suggesting it can detect early subclinical myocardial systolic dysfunction.

Limitations

  • Unavailability of some echocardiographic techniques to perform circumferential measurements
  • Measurements were studied only during the acute phase without later follow-up
  • Inability to exclude patients with subclinical myocarditis
  • Unavailability of some echocardiographic techniques, resulting in inability to perform circumferential measurements
  • Studied only during the acute phase of the disease without follow-up

Cite This Study

Hematian et al. (2015) conducted a case-control in Kawasaki Disease (n=51). Kawasaki Disease (acute phase) vs. Healthy controls was evaluated on Global Strain (%) (p=<0.001). Kawasaki Disease in the acute phase was associated with significantly reduced mean global strain (17.03% vs 20.22%) and strain rate (1.66 vs 1.97 1/s) compared to healthy controls.

synapsesocial.com/papers/6a18e0c6c9d74cf65281fc0dhttps://doi.org/10.5812/ijp.25(3)2015.198

Topics

Echocardiography
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An exercise tissue Doppler and strain rate imaging study of diastolic myocardial dysfunction after Kawasaki syndrome in childhood2007 · 24 citations
  2. 2Quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography2013 · 16 citations
  3. 3Assessment of Regional Right Ventricular Velocities, Strain, and Displacement in Normal Children Using Velocity Vector Imaging2007 · 56 citations
  4. 4Myocardial Velocity, Strain, and Strain Rate Abnormalities in Healthy Obese Children2007 · 51 citations
  5. 5Abnormal myocardial deformation properties in obese, non-hypertensive children: an ambulatory blood pressure monitoring, standard echocardiographic, and strain rate imaging study2007 · 9 citations