Key result
Children with acute Kawasaki disease had significantly lower global longitudinal strain (-12.94 vs. -15.29, P=0.04) and strain rate compared with age-matched controls despite normal systolic function.
Why the study?
Does velocity vector imaging (VVI)-derived left ventricular myocardial strain and strain rate detect subtle myocardial abnormalities in children with acute Kawasaki disease compared to controls?
Population
54 children, comprising 32 with acute Kawasaki disease and 22 age-matched controls.
Comparison
Velocity vector imaging to measure peak systolic… vs Age-matched controls.
Design
Case-control
Authors
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May detect subclinical LV dysfunction in acute Kawasaki disease; hypothesis-generating and requires prospective validation before clinical use.
Case-Control (n=54)
Does velocity vector imaging (VVI)-derived left ventricular myocardial strain and strain rate detect subtle myocardial abnormalities in children with acute Kawasaki disease compared to controls?
Absolute Event Rate: -12.94% vs -15.29%
p-value: p=0.04
Velocity vector imaging reveals reduced longitudinal LV strain and strain rate in acute Kawasaki disease despite normal routine echocardiographic systolic function, offering a sensitive marker for myocardial inflammation.
McCandless et al. (2013) conducted a case-control in Kawasaki disease (n=54). Acute Kawasaki disease vs. Age-matched controls was evaluated on Global longitudinal strain (ε) (p=0.04). Children with acute Kawasaki disease had significantly lower global longitudinal strain (-12.94 vs. -15.29, P=0.04) and strain rate compared with age-matched controls despite normal systolic function.
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