Key result
Children long-term after arterial switch operation for transposition of the great arteries had lower maximum oxygen consumption than healthy controls.
Why the study?
Does arterial switch operation for TGA result in preserved long-term exercise capacity compared to healthy children?
Observational (n=60)
Does arterial switch operation for TGA result in preserved long-term exercise capacity compared to healthy children?
Children with TGA long-term after ASO have well-preserved exercise capacity, though slightly lower than healthy controls, potentially due to chronotropic incompetence.
Answers are grounded in this paper and cite their sources.
Supports well-preserved exercise capacity long-term after ASO; extends observational data but leaves open mechanistic and outcome questions.
UNLABELLED: Transposition of the great arteries (TGA) is a congenital heart defect successfully corrected through arterial switch operation (ASO). Although this technique had significant impact in improving survival, little is known about the functional capacity of the operated patients long-term after surgery. OBJECTIVE: The aim of this study was to compare the functional capacity of children with TGA long-term after ASO with that of healthy children. DESIGN: Retrospective study. PATIENTS: All patients that performed cardiopulmonary exercise test (CPET) were included in the study. As a control group, healthy children in evaluation for physical activity that performed CPET during the same period were also enrolled. RESULTS: Thirty-one TGA patients (19 male) were compared with 29 age-matched controls (21 male). Maximum oxygen consumption was higher in the control group (45.47 ± 8.05 vs. 40.52 ± 7.19, P = .017), although within normal limits in both groups (above 90% of predicted value). The heart rate behavior during exercise was different in both groups, with a mean chronotropic index significantly lower in the TGA group (63% ± 14 vs. 81% ± 12, P < .001). CONCLUSIONS: Our results showed that exercise capacity long-term after ASO in TGA is well preserved although lower than in healthy children what might be explained by the presence of chronotropic incompetence in the TGA group.
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Samos et al. (2015) conducted an observational in Transposition of the great arteries (n=60). Arterial switch operation vs. Healthy children was evaluated on Maximum oxygen consumption (p=.017). Children long-term after arterial switch operation for transposition of the great arteries had lower maximum oxygen consumption than healthy controls.
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