Key result
Neuregulins play an important role in transducing signals between the heart's microvasculature and cardiomyocytes, offering potential strategies to heal acquired and congenital heart diseases.
This review highlights the critical role of neuregulin signaling in heterocellular communication within the heart and its potential as a therapeutic target for cardiac healing.
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Neuregulin signaling merits exploration as a therapeutic target; leaves open clinical translation in heart disease.
Heterocellular communication in the heart is an important mechanism for matching circulatory demands with cardiac structure and function, and neuregulins (Nrgs) play an important role in transducing this signal between the hearts' vasculature and musculature. Here, we review the current knowledge regarding Nrgs, explaining their roles in transducing signals between the heart's microvasculature and cardiomyocytes. We highlight intriguing areas being investigated for developing new, Nrg-mediated strategies to heal the heart in acquired and congenital heart diseases, and note avenues for future research.
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Parodi et al. (2014) conducted a review in Acquired and congenital heart diseases. Neuregulins (Nrgs) was evaluated. Neuregulins play an important role in transducing signals between the heart's microvasculature and cardiomyocytes, offering potential strategies to heal acquired and congenital heart diseases.
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