Why the study?
Are serum IL-6 levels elevated in women with polycystic ovary syndrome compared to controls, and are they related to hormonal and metabolic profiles?
Case-Control (n=80)
Are serum IL-6 levels elevated in women with polycystic ovary syndrome compared to controls, and are they related to hormonal and metabolic profiles?
Elevated serum IL-6 levels in women with PCOS appear to be driven by nutritional status and BMI rather than the syndrome itself, potentially serving as a predictor for cardiometabolic risks.
Answers are grounded in this paper and cite their sources.
IL-6 elevation in PCOS may reflect BMI rather than the syndrome; leaves open its cardiometabolic predictive value in prospective studies.
Objective: The aim of this study was to evaluate serum concentrations of interleukin-6 (IL-6) in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS).Methods: A total of 40 women with PCOS and 40 age-matched controls were eligible for the study. Hirsutism scores, hormonal and metabolic profile as well as IL-6 levels were evaluated in each subject.Results: Women with PCOS exhibited higher body mass index (BMI) and serum concentrations of IL-6 levels than controls (p < 0.05); however, levels of IL-6 were not significantly increased when compared with BMI-matched controls (p > 0.05). IL-6 levels were significantly correlated positively with BMI and triglyceride levels; however, negatively correlated with high-density lipoprotein levels.Conclusion: The data of this study suggested that serum IL-6 levels were found to be higher in women with PCOS as compared to controls; however, IL-6 levels might be dependent on nutritional status but not on PCOS per se. Raised serum IL-6 levels may be related to BMI and serum lipid levels and may be a predictor for cardiometabolic risks.
No takes yet. Share an insight, caveat, or question.
Küçük et al. (2014) conducted a case-control in Polycystic ovary syndrome (n=80). Polycystic ovary syndrome vs. Age-matched and BMI-matched controls was evaluated on Serum concentrations of interleukin-6 (IL-6) (p=< 0.05).
Synapse has enriched 10 related papers. Consider them for comparative context: