Key result
Serum IL-18 levels were significantly increased in women with polycystic ovary syndrome compared with healthy controls (P=0.031) and in obese women compared with lean women (P=0.018).
Why the study?
Are serum IL-18 concentrations increased in women with PCOS compared to healthy controls, and how do they relate to obesity and insulin resistance?
Population
94 women (60 consecutive women with polycystic ovary syndrome [PCOS] and 34 healthy women)
Design
Case-control
Authors
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IL-18 elevation may signal inflammation-related cardiovascular risk in PCOS and obesity; leaves open causal role pending prospective studies.
Case-Control (n=94)
Are serum IL-18 concentrations increased in women with PCOS compared to healthy controls, and how do they relate to obesity and insulin resistance?
p-value: p=0.031
PCOS and obesity are associated with increased serum IL-18 levels, which correlate with adiposity and insulin resistance, suggesting a link to low-grade chronic inflammation and cardiovascular risk.
Escobar‐Morreale et al. (2004) conducted a case-control in Polycystic Ovary Syndrome (n=94). Polycystic Ovary Syndrome and Obesity vs. Healthy controls and lean women was evaluated on Serum IL-18 concentrations (p=0.031). Serum IL-18 levels were significantly increased in women with polycystic ovary syndrome compared with healthy controls (P=0.031) and in obese women compared with lean women (P=0.018).
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