What is the clinical evidence from this study?

Study design: Observational. Population: Polycystic ovary syndrome (n=642). Intervention: Insulin resistance vs. Non-insulin resistance. Primary outcome: Levels of hs-CRP, TNF-α, and IL-6.

February 4, 2022Cellular and Molecular BiologyOpen Access

Changes in inflammatory factors, oxidative stress, glucose and lipid metabolism, and insulin resistance in patients with polycystic ovary syndrome

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Key result

Insulin resistance in patients with polycystic ovary syndrome was associated with higher levels of hs-CRP (5.9 vs 4.6 mg/L), TNF-α (9.2 vs 6.3 μg/L), and IL-6 (87.2 vs 51.5 ng/ml).

Population

642 polycystic ovary patients in the first half of 2019, divided into insulin resistance and non-insulin…

Design

Cross-sectional

Authors

PZPeiwen Zhong BGBaoxing Guan YLYanting Lin

Discussion

Member takes

Overview

Insulin resistance links to higher inflammation in PCOS; hypothesis-generating and should not yet change practice.

Study Design

Type

Observational (n=642)

Structured PICO

Population

642 women with polycystic ovary syndrome evaluated for inflammatory factors, oxidative stress, and glucose and lipid metabolism based on insulin resistance status.

Outcome

Changes in inflammatory factors, oxidative stress, glucose and lipid metabolism, and insulin resistancesurrogate

Patients with polycystic ovary syndrome and insulin resistance exhibit higher levels of inflammatory markers (hs-CRP, TNF-α, IL-6) compared to those without insulin resistance.

Cite This Study

Zhong et al. (2022) conducted an observational in Polycystic ovary syndrome (n=642). Insulin resistance vs. Non-insulin resistance was evaluated on Levels of hs-CRP, TNF-α, and IL-6. Insulin resistance in patients with polycystic ovary syndrome was associated with higher levels of hs-CRP (5.9 vs 4.6 mg/L), TNF-α (9.2 vs 6.3 μg/L), and IL-6 (87.2 vs 51.5 ng/ml).

synapsesocial.com/papers/6ab1e4e7bd887923dec46709 https://doi.org/10.14715/cmb/2021.67.5.6

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February 4, 2022Cellular and Molecular BiologyOpen Access

Changes in inflammatory factors, oxidative stress, glucose and lipid metabolism, and insulin resistance in patients with polycystic ovary syndrome

View Full Paper

Ask AI

Bookmark

Key result

Insulin resistance in patients with polycystic ovary syndrome was associated with higher levels of hs-CRP (5.9 vs 4.6 mg/L), TNF-α (9.2 vs 6.3 μg/L), and IL-6 (87.2 vs 51.5 ng/ml).

Population

642 polycystic ovary patients in the first half of 2019, divided into insulin resistance and non-insulin…

Design

Cross-sectional

Authors

PZPeiwen Zhong BGBaoxing Guan YLYanting Lin

Discussion

Member takes

Overview

Insulin resistance links to higher inflammation in PCOS; hypothesis-generating and should not yet change practice.

Study Design

Type

Observational (n=642)

Structured PICO

Population

642 women with polycystic ovary syndrome evaluated for inflammatory factors, oxidative stress, and glucose and lipid metabolism based on insulin resistance status.

Outcome

Changes in inflammatory factors, oxidative stress, glucose and lipid metabolism, and insulin resistancesurrogate

Patients with polycystic ovary syndrome and insulin resistance exhibit higher levels of inflammatory markers (hs-CRP, TNF-α, IL-6) compared to those without insulin resistance.

Cite This Study

synapsesocial.com/papers/6ab1e4e7bd887923dec46709 https://doi.org/10.14715/cmb/2021.67.5.6

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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