What is the clinical evidence from this study?

Study design: Other. Population: Bileaflet mechanical heart valve flow. Intervention: Computational fluid dynamics simulation of 23 mm St. Jude Medical Regent valve. Primary outcome: Platelet damage (Blood Damage Index).

What does this research mean for the field?

In a multiscale computational simulation of a 23 mm St. Jude Medical Regent bileaflet mechanical heart valve, no platelets exceed activation thresholds during the cardiac cycle, with the highest damage occurring in recirculation zones and leakage flow gaps. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 29, 2014Journal of Biomechanical EngineeringOpen Access

Blood Damage Through a Bileaflet Mechanical Heart Valve: A Quantitative Computational Study Using a Multiscale Suspension Flow Solver

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Key result

A multiscale computational simulation of a 23 mm St. Jude Medical Regent bileaflet mechanical heart valve demonstrated that no platelets exceeded activation thresholds during the cardiac cycle.

Population

Computational model of pulsatile flow through a 23 mm St. Jude Medical Regent™ valve in the aortic position…

Design

Preclinical

Authors

BYB. Min Yun CACyrus K. Aidun AYAjit P. Yoganathan

Discussion

Member takes

Overview

Does not warrant practice changes for mechanical valves; leaves open in vivo validation of computational models.

Structured PICO

Population

Computational model of pulsatile flow through a 23 mm St. Jude Medical (SJM) Regent™ valve in the aortic position with thousands of suspended platelets

Intervention

Multiscale numerical method (lattice-Boltzmann method) modeling suspended platelets

Outcome

Platelet damage potential (activation thresholds, damage in recirculation zones and leakage flow)surrogate

Computational modeling reveals that platelet damage in bileaflet mechanical heart valves is highest in recirculation zones and diastolic leakage flow, highlighting areas for future device optimization.

Limitations

Hinge regions cannot be resolved at the current spatial resolution.
The number of simulated platelets (5400) is several orders of magnitude less than realistic in vivo numbers.
Only one cardiac cycle was modeled for the simulations.
Idealized modeling of the sinus root.
One-way fluid-solid interaction was used for modeling platelets to save computational costs.

Cite This Study

Yun et al. (2014) studied Bileaflet mechanical heart valve flow. Computational fluid dynamics simulation of 23 mm St. Jude Medical Regent valve was evaluated on Platelet damage (Blood Damage Index). A multiscale computational simulation of a 23 mm St. Jude Medical Regent bileaflet mechanical heart valve demonstrated that no platelets exceeded activation thresholds during the cardiac cycle.

synapsesocial.com/papers/6a13d13f496bd0bf6e39f438 https://doi.org/10.1115/1.4028105

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July 29, 2014Journal of Biomechanical EngineeringOpen Access

Blood Damage Through a Bileaflet Mechanical Heart Valve: A Quantitative Computational Study Using a Multiscale Suspension Flow Solver

View Full Paper

Ask AI

Bookmark

Key result

A multiscale computational simulation of a 23 mm St. Jude Medical Regent bileaflet mechanical heart valve demonstrated that no platelets exceeded activation thresholds during the cardiac cycle.

Population

Computational model of pulsatile flow through a 23 mm St. Jude Medical Regent™ valve in the aortic position…

Design

Preclinical

Authors

BYB. Min Yun CACyrus K. Aidun AYAjit P. Yoganathan

Discussion

Member takes

Overview

Does not warrant practice changes for mechanical valves; leaves open in vivo validation of computational models.

Structured PICO

Population

Computational model of pulsatile flow through a 23 mm St. Jude Medical (SJM) Regent™ valve in the aortic position with thousands of suspended platelets

Intervention

Multiscale numerical method (lattice-Boltzmann method) modeling suspended platelets

Outcome

Platelet damage potential (activation thresholds, damage in recirculation zones and leakage flow)surrogate

Limitations

Hinge regions cannot be resolved at the current spatial resolution.
The number of simulated platelets (5400) is several orders of magnitude less than realistic in vivo numbers.
Only one cardiac cycle was modeled for the simulations.
Idealized modeling of the sinus root.
One-way fluid-solid interaction was used for modeling platelets to save computational costs.

Cite This Study

synapsesocial.com/papers/6a13d13f496bd0bf6e39f438 https://doi.org/10.1115/1.4028105

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