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July 1, 1993ASAIO Journal

Relative Blood Damage in the Three Phases of a Prosthetic Heart Valve Flow Cycle

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Population

In vitro blood flow loops using fresh porcine blood and a Bjork-Shiley monostrut Delrin disk valve operating…

Design

Preclinical

Authors

TLTheodore C. LamsonGRGerson RosenbergDGDavid B. Geselowitz

Discussion

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Overview

Enables phase-specific hemolysis testing of VAD prosthetic valves; leaves open clinical translation pending further validation.

Structured PICO

P
Population
In vitro blood flow loops using fresh porcine blood and a Bjork-Shiley monostrut Delrin disk valve operating in a Penn State Electric Left Ventricular Assist Device (PS LVAD)
I
Intervention
Simulation of three phases of a prosthetic heart valve flow cycle: forward flow, rapid valve closure, and regurgitant back flow
O
Outcome
Rate of hemolysis (index of hemolysis, IH)surrogate

An in vitro model was developed to separately analyze the hemolytic potential of the three flow phases of a prosthetic heart valve operating in a ventricular assist device.

Cite This Study

Lamson et al. (1993) studied this question.

synapsesocial.com/papers/6a855cb035bc0eada8d5989bhttps://doi.org/10.1097/00002480-199339030-00091
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relative Blood Damage in the Three Phases of a Prosthetic Heart Valve Flow Cycle1993 · 17 citations
  2. 2Blood Damage Through a Bileaflet Mechanical Heart Valve: A Quantitative Computational Study Using a Multiscale Suspension Flow Solver2014 · 31 citations
  3. 3Near Valve Flows and Potential Blood Damage During Closure of a Bileaflet Mechanical Heart Valve2011 · 13 citations
  4. 4Flow Visualization of A Monoleaflet and Bileaflet Mechanical Heart Valve in A Pneumatic Ventricular Assist Device Using A PIV System2010 · 6 citations
  5. 5Unsteady Fluid Dynamics of Several Mechanical Prosthetic Heart Valves Using a Two Component Laser Doppler Anemometer System1997 · 15 citations