Key result
Prosthetic valve back flow produces hemolysis comparable to forward flow, increasing markedly with cavitation duration.
Why the study?
How do the different phases of a prosthetic heart valve flow cycle contribute to blood damage (hemolysis) in a ventricular assist device?
Population
In vitro blood flow loops using fresh porcine blood and a Bjork-Shiley monostrut Delrin disk valve operating…
Comparison
Three phases of prosthetic heart valve flow cycle vs Comparison among the three flow phases
Design
Preclinical
Authors
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Backflow may substantially contribute to hemolysis in LVADs; hypothesis-generating for valve design until confirmed in clinical studies.
How do the different phases of a prosthetic heart valve flow cycle contribute to blood damage (hemolysis) in a ventricular assist device?
In vitro studies demonstrate that regurgitant back flow through a closed prosthetic valve in an LVAD contributes to hemolysis comparably to forward flow, and hemolysis increases markedly with cavitation potential.
Lamson et al. (1993) studied Prosthetic heart valve operating in a ventricular assist device. Three phases of a prosthetic heart valve flow cycle (forward flow, valve closure, backflow) was evaluated on Rate of hemolysis, characterized by the index of hemolysis (IH). The hemolytic effects of back flow are comparable to forward flow, contributing significantly to the overall index of hemolysis, which increases markedly with expected cavitation cycle duration.
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