Key result
Hemolysis and platelet activation induced by a typical resistance valve are equivalent to 17%-45% and 14%-60%, respectively, of those induced by the blood pump itself.
Why the study?
Blood damage induced by in-vitro circulatory testing loop components such as the resistance valve may affect the accuracy, reproducibility, and intercomparability of blood pump test results.
Comparison
Resistance valve with different openings vs pump models across different operating points
Design
Computational fluid dynamics simulation study
Authors
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Valve contribution to hemolysis and platelet activation warrants design scrutiny in circulatory devices; leaves open whether modifications improve clinical hemocompatibility.
Resistance valves in in-vitro testing loops cause significant hemolysis and platelet activation, which can confound the hemocompatibility evaluation of blood pumps.
Wu et al. (2023) studied Hemolysis and platelet activation in blood pumps. Resistance valve vs. Pump alone was evaluated on Valve-to-pump ratio of hemolysis and platelet activation. Hemolysis and platelet activation induced by a typical resistance valve are equivalent to 17%-45% and 14%-60%, respectively, of those induced by the blood pump itself.
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