Why the study?
Does a mechanical heart valve prosthesis with a tilting disc cause hemolysis in an in vitro model?
Population
In vitro model using human banked blood in a test chamber with an artificial ventricle
Design
Preclinical
Authors
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Supports in vitro lysis testing to estimate hemolysis with tilting-disc valves; leaves open validation in modern prostheses and patients.
Does a mechanical heart valve prosthesis with a tilting disc cause hemolysis in an in vitro model?
In vitro hemolysis testing using a lysis number can estimate erythrocyte survival time in patients with mechanical heart valves, showing agreement with clinical observations.
Wendt et al. (1992) studied this question.
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