Key result
In an in-vitro model, a stiff aortic root setup increased free plasma hemoglobin compared to a flexible setup for both the Triflo (19.3 vs 13.4 mg/dl) and SJM (42.7 vs 22.2 mg/dl) mechanical valves.
Why the study?
Does a stiff aortic root increase hemolysis in mechanical heart valve prostheses compared to a compliant aortic root in an in-vitro model?
Population
In vitro pulsatile blood tester using porcine blood
Comparison
Mechanical heart valves tested in a stiff aorta… vs The same mechanical heart valves tested in a…
Design
Preclinical
Follow-up
3 hours
Authors
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Stiff aortic roots may increase mechanical valve hemolysis; leaves open clinical relevance and need for in-vivo studies.
Does a stiff aortic root increase hemolysis in mechanical heart valve prostheses compared to a compliant aortic root in an in-vitro model?
A stiff aortic root increases hemolysis in mechanical heart valve prostheses compared to a compliant aortic root in an in-vitro model, potentially due to higher closing speeds and cavitation.
Linde et al. (2012) studied Mechanical heart valve hemolysis. Stiff aorta setup vs. Compliant (flexible) aorta setup was evaluated on Increase in free plasma hemoglobin. In an in-vitro model, a stiff aortic root setup increased free plasma hemoglobin compared to a flexible setup for both the Triflo (19.3 vs 13.4 mg/dl) and SJM (42.7 vs 22.2 mg/dl) mechanical valves.
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