Key result
In vitro testing of prosthetic heart valves showed mean hemolysis indices of 0.010-0.035 for aortic and 0.004-0.021 for mitral valves, with the Gott-Daggett valve being the most hemolytic.
Why the study?
Do different prosthetic heart valves cause varying degrees of immediate hemolysis in vitro?
Population
In vitro steady- and pulsatile-flow systems
Comparison
Eight aortic and five mitral valve prostheses vs Comparison among different valve types
Design
Preclinical
Authors
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May inform valve selection amid hemolysis concerns; leaves open in vivo clinical correlation.
Do different prosthetic heart valves cause varying degrees of immediate hemolysis in vitro?
In vitro testing demonstrates that different prosthetic heart valves cause varying degrees of hemolysis, which may be clinically significant regarding hemoglobin clearance and red cell regeneration.
Indeglia et al. (1968) studied Prosthetic heart valves (in vitro hemolysis). Prosthetic heart valves was evaluated on Index of hemolysis (IH). In vitro testing of prosthetic heart valves showed mean hemolysis indices of 0.010-0.035 for aortic and 0.004-0.021 for mitral valves, with the Gott-Daggett valve being the most hemolytic.
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