Key result
Mitral valve replacement with a Starr-Edwards prosthesis caused chronic intravascular hemolysis in 85% of patients, compared to no comparable evidence in those receiving an aortic homograft.
Why the study?
Does mitral valve replacement with a Starr-Edwards prosthesis increase chronic intravascular hemolysis compared to an aortic homograft in patients undergoing mitral valve replacement?
Population
41 patients following mitral valve replacement
Comparison
Mitral valve replacement with a composite seat… vs Mitral valve replacement with a gamma-radiated…
Design
Cohort
Authors
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Starr-Edwards mitral replacement was associated with chronic hemolysis; leaves open relevance to contemporary mechanical valves.
Cohort (n=41)
Does mitral valve replacement with a Starr-Edwards prosthesis increase chronic intravascular hemolysis compared to an aortic homograft in patients undergoing mitral valve replacement?
Absolute Event Rate: 85% vs 0%
p-value: p=<0.001
Mitral valve replacement with a Starr-Edwards prosthesis is associated with a significantly higher incidence of chronic intravascular hemolysis compared to a gamma-radiated aortic homograft.
Donnelly et al. (1973) conducted a cohort in Mitral valve replacement (n=41). Composite seat Starr-Edwards prosthesis vs. Gamma-radiated frame-mounted aortic homograft was evaluated on Evidence of chronic intravascular hemolysis (p=<0.001). Mitral valve replacement with a Starr-Edwards prosthesis caused chronic intravascular hemolysis in 85% of patients, compared to no comparable evidence in those receiving an aortic homograft.
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