Key result
Calf or pig valve heterografts resulted in no haemolytic anaemia and a 20.8% rate of subclinical haemolysis at 3 to 9 months post-surgery.
Why the study?
Do calf or pig valve heterografts cause intravascular haemolysis in patients with severe valvular heart disease?
Observational (n=24)
Do calf or pig valve heterografts cause intravascular haemolysis in patients with severe valvular heart disease?
Calf or pig heterograft valves do not cause significant haemolytic anaemia, behaving similarly to human valves rather than artificial prostheses.
Supports heterograft valve safety from clinical haemolysis; leaves open need for larger prospective confirmation.
Intravascular haemolysis was studied in 24 patients three to nine months after calf or pig valve heterografts had been inserted for severe valvular heart disease. No patient had haemolytic anaemia. In five of the 24 patients there was subclinical haemolysis, and in these five the haemolysis appeared to be related to residual aortic regurgitation or to the presence of other foreign material such as a Dacron aortic graft. The extent of postoperative haemolysis in these five patients was comparable to that observed preoperatively in patients with valvular heart disease.The results support the belief that, in contrast to artificial valve prostheses, heterograft valves behave similarly to human valves as regards haemolysis.
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Roeser et al. (1968) conducted an observational in Severe valvular heart disease (n=24). Calf or pig valve heterografts was evaluated on Haemolytic anaemia. Calf or pig valve heterografts resulted in no haemolytic anaemia and a 20.8% rate of subclinical haemolysis at 3 to 9 months post-surgery.
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