Key result
Homograft replacement of the aortic valve was associated with normal red cell survival (T½ 51Cr 24 to 34 days) and no haemolysis, even in patients with regurgitation.
Why the study?
Does homograft replacement of the aortic valve cause haemolysis in patients?
Observational (n=21)
Does homograft replacement of the aortic valve cause haemolysis in patients?
Homograft replacement of the aortic valve is not associated with significant haemolysis, even in the presence of valvular regurgitation.
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May support no haemolysis with aortic homografts even with regurgitation; hypothesis-generating and requires larger prospective confirmation.
Yacoub et al. (1969) conducted an observational in Following homograft replacement of the aortic valve (n=21). Homograft replacement of the aortic valve was evaluated on Red cell survival (T½ 51Cr). Homograft replacement of the aortic valve was associated with normal red cell survival (T½ 51Cr 24 to 34 days) and no haemolysis, even in patients with regurgitation.
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