Key result
A novel in vitro pulsatile flow facility successfully simulated physiological conditions to evaluate the hemodynamics and thrombogenicity of a 23 mm St. Jude Medical mechanical heart valve.
The developed in vitro pulsatile flow facility is capable of simultaneously characterizing blood damage and fluid dynamics for prosthetic heart valves.
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Novel in vitro facility enables simultaneous valve testing; leaves open validation against clinical outcomes before guiding practice.
Arjunon et al. (2015) studied Prosthetic heart valve thrombogenicity. Pulsatile flow facility test-platform was evaluated on Blood damage (TAT, PF1.2, hemolysis) and fluid dynamics. A novel in vitro pulsatile flow facility successfully simulated physiological conditions to evaluate the hemodynamics and thrombogenicity of a 23 mm St. Jude Medical mechanical heart valve.
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