Key result
An in vitro test model using bovine blood reproducibly identified thrombogenic sites within cardiovascular test devices similar to those observed in implanted devices.
Population
In vitro test model using fresh bovine heparinized blood in a pneumatically driven 50 cc polyurethane…
Design
Preclinical
Follow-up
2-3 hours per experiment
Authors
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May aid preclinical device thrombogenicity screening; leaves open clinical predictive validity.
A novel in vitro test model using bovine blood can reproducibly identify thrombogenic sites in cardiovascular devices, aiding in preclinical device evaluation.
Swier et al. (1989) studied Cardiovascular device thrombogenicity. In vitro test model was evaluated on Thrombus deposition and identification of thrombogenic sites. An in vitro test model using bovine blood reproducibly identified thrombogenic sites within cardiovascular test devices similar to those observed in implanted devices.
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