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May 1, 2009The International Journal of Artificial Organs

Development and Evaluation of a Novel Artificial Catheter-Deliverable Prosthetic Heart Valve and Method for in Vitro Testing

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Population

In vitro model using a modified left heart simulator (Lhs) and a tensile testing device

Comparison

Novel artificial percutaneous heart valve… vs Existing tissue-based percutaneous heart valves

Design

Preclinical

Authors

TCThomas E. ClaiborneDBDanny BluesteinRSRichard T. Schoephoerster

Discussion

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Overview

May support iterative PhV development; leaves open in vivo durability and clinical translation.

Structured PICO

P
Population
In vitro model using a modified left heart simulator (Lhs) and a tensile testing device
I
Intervention
Novel artificial percutaneous heart valve (PhV) constructed from polymers, metals and fabrics
C
Comparator
Existing tissue-based percutaneous heart valves (comparative reference)
O
Outcome
Hydrodynamic performance (mean transvalvular pressure gradient, mean regurgitant fraction) and static performance (resistance to migration, resistance to crushing, crimpability)surrogate

A novel artificial percutaneous heart valve demonstrated favorable in vitro hydrodynamic and static performance, suggesting feasibility as an alternative to tissue-based valves.

Cite This Study

Claiborne et al. (2009) studied this question.

synapsesocial.com/papers/6a9080d3e16d749e8fc928cdhttps://doi.org/10.1177/039139880903200503
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transluminal implantation of artificial heart valves. Description of a new expandable aortic valve and initial results with implantation by catheter technique in closed chest pigs1992 · 492 citations
  2. 2Percutaneous Transcatheter Implantation of an Aortic Valve Prosthesis for Calcific Aortic Stenosis2002 · 3,196 citations
  3. 3A novel polymer for potential use in a trileaflet heart valve2006 · 75 citations
  4. 4Mechanical versus bioprosthetic valve replacement in middle-aged patients2006 · 150 citations