Why the study?
Clinically available prosthetic heart valves are imperfect, with mechanical valves requiring anticoagulation and bioprosthetic valves having limited durability, whereas polymer valves offer potential durability without anticoagulation.
Population
Sheep models for extra-vivo (n = 8) and in vivo testing (n = 3), plus bench testing
Comparison
Novel polymeric heart valve vs best-in-class bioprosthesis on bench testing
Design
Preclinical in vitro bench-testing, extra-vivo evaluation, and in vivo animal feasibility study
Follow-up
1-24 hours
Authors
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Short-term polymer valve feasibility shown; leaves open long-term durability and clinical trials.
A novel polymeric heart valve prosthesis showed promising bench durability and short-term in vivo feasibility, supporting further long-term efficacy trials.
Stasiak et al. (2020) studied this question.
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