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November 1, 2015The International Journal of Artificial OrgansOpen Access

Fluid Dynamic Characterization of a Polymeric Heart Valve Prototype (Poli-Valve) Tested under Continuous and Pulsatile Flow Conditions

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Key result

Two types of Poli-Valves met the minimum ISO 5840 Standard requirements for regurgitation and effective orifice area when compared to 5 mechanical and 5 tissue heart valves.

Population

In vitro testing model for prosthetic heart valves

Comparison

2 types of Poli-Valves vs 5 mechanical heart valves and 5 tissue heart…

Design

Preclinical

Authors

FGFrancesco De GaetanoMSMarta SerraniPBPaola Bagnoli

Discussion

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Overview

Poli-valves meet ISO hydrodynamic standards in vitro; leaves open translation to durable clinical performance.

Structured PICO

P
Population
In vitro testing model for prosthetic heart valves
I
Intervention
2 types of Poli-Valves (supra-annular, trileaflet prosthetic heart valves made from styrenic block copolymers differing in polystyrene fraction content)
C
Comparator
5 mechanical heart valves (MHVs) and 5 tissue heart valves (THVs) currently available on the market
O
Outcome
Pressure drops, effective orifice area (EOA), and regurgitant volume under continuous and pulsatile flow conditions as prescribed by ISO 5840 Standardsurrogate

In vitro testing demonstrates that novel polymeric heart valves made from styrenic block copolymers meet ISO standards for hydrodynamic performance, indicating potential as a future alternative to mechanical and biological valves.

Cite This Study

Gaetano et al. (2015) studied Heart valve replacement. Poli-Valves (polymeric heart valves) vs. Mechanical and tissue heart valves was evaluated on Pressure drops, effective orifice area (EOA), and regurgitant volume. Two types of Poli-Valves met the minimum ISO 5840 Standard requirements for regurgitation and effective orifice area when compared to 5 mechanical and 5 tissue heart valves.

synapsesocial.com/papers/6a9546f76d8ecf100b25e3e2https://doi.org/10.5301/ijao.5000452
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Also Consider

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  1. 1New Flexible Polymeric Heart Valve Prostheses for the Mitral and Aortic Positions2004 · 51 citations
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  4. 4Development and Evaluation of a Novel Artificial Catheter-Deliverable Prosthetic Heart Valve and Method for in Vitro Testing2009 · 25 citations
  5. 5Biocompatibility and Fatigue Properties of Polystyrene−Polyisobutylene−Polystyrene, an Emerging Thermoplastic Elastomeric Biomaterial2006 · 108 citations