Key result
Patient-specific computational testing of a second-generation percutaneous pulmonary valve device showed good agreement with in vitro data, demonstrating optimal stent anchoring and deformation.
Case Report (n=1)
An experimentally validated computational model can accurately simulate percutaneous pulmonary valve implantation, potentially aiding in preclinical device characterization and patient selection.
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May aid preclinical device testing; leaves open clinical translation for percutaneous pulmonary valve implantation.
AIMS: To validate patient-specific computational testing of a second-generation device for percutaneous pulmonary valve implantation (PPVI), against realistic in vitro data. METHODS AND RESULTS: Tests were initially carried out in a simple loading mode, performing a compliance test on a rapid prototyped cylinder. This model was reproduced computationally and validated against the experimental data. A second-generation PPVI stent-graft, with no valve mounted, was then deployed in a simplified cylindrical geometry, measuring its displacement when subjected to a pressure pulse. Experimental and computational measurements were in good agreement. Finally, having selected a patient regarded as unsuitable for first-generation PPVI, but potentially suitable for a second-generation device, the stent-graft was studied in the rapidly prototyped patient-specific right ventricular outflow tract (RVOT). Stent positioning and radial displacements with pulsatile flow were observed in a mock circuit using fluoroscopy imaging. Stent deformation and anchoring were measured both in vitro and computationally. Both tests indicated that the stent was well anchored in the RVOT, especially in the distal position, and its central region was rounded, ensuring, were a valve present, optimal valve function. CONCLUSION: We suggest that an experimentally validated computational model can be used for preclinical device characterisation and patient selection.
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Biglino et al. (2012) conducted a case report in Unsuitable for first-generation percutaneous pulmonary valve implantation (n=1). Patient-specific computational testing of a second-generation PPVI device vs. In vitro experimental data was evaluated on Stent deformation, anchoring, and radial displacements. Patient-specific computational testing of a second-generation percutaneous pulmonary valve device showed good agreement with in vitro data, demonstrating optimal stent anchoring and deformation.
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