Key result
The cardiac simulator successfully replicated physiological left ventricular pressure, aortic pressure, and aortic flow waves at 60, 80, and 100 beats per minute, validating its use for in vitro evaluation of prosthetic heart valves.
The experimental validation of this cardiac simulator demonstrates its capability to replicate human physiological hemodynamics, enabling future in vitro hydrodynamic testing of prosthetic heart valves.
Enables in vitro prosthetic valve testing; leaves open correlation with clinical performance.
OBJECTIVE: This work describes the experimental validation of a cardiac simulator for three heart rates (60, 80 and 100 beats per minute), under physiological conditions, as a suitable environment for prosthetic heart valves testing in the mitral or aortic position. METHODS: In the experiment, an aortic bileaflet mechanical valve and a mitral bioprosthesis were employed in the left ventricular model. A test fluid of 47.6% by volume of glycerin solution in water at 36.5ºC was used as blood analogue fluid. A supervisory control and data acquisition system implemented previously in LabVIEW was applied to induce the ventricular operation and to acquire the ventricular signals. The parameters of the left ventricular model operation were based on in vivo and in vitro data. The waves of ventricular and systemic pressures, aortic flow, stroke volume, among others, were acquired while manual adjustments in the arterial impedance model were also established. RESULTS: The acquired waves showed good results concerning some in vivo data and requirements from the ISO 5840 standard. CONCLUSION: The experimental validation was performed, allowing, in future studies, characterizing the hydrodynamic performance of prosthetic heart valves.
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Bazan et al. (2016) studied Prosthetic heart valve testing. Cardiac simulator (left ventricular model) vs. In vivo physiological data and ISO 5840 standard requirements was evaluated on Replication of physiological pressure and flow waves (LVP, AoP, AoF, SV) at 60, 80, and 100 bpm. The cardiac simulator successfully replicated physiological left ventricular pressure, aortic pressure, and aortic flow waves at 60, 80, and 100 beats per minute, validating its use for in vitro evaluation of prosthetic heart valves.
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