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May 16, 2008Journal of Biomechanical Engineering

A Detailed Fluid Mechanics Study of Tilting Disk Mechanical Heart Valve Closure and the Implications to Blood Damage

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Population

In vitro model of a tilting disk mechanical heart valve in a 'single shot' chamber driven by a pneumatic pump

Design

Preclinical

Authors

KMKeefe B. ManningLHLuke H. HerbertsonAFArnold A. Fontaine

Discussion

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Overview

Extreme shear at mechanical valve closure may promote hemolysis and thrombosis; animal data leave open human translation.

Structured PICO

P
Population
In vitro model of a tilting disk mechanical heart valve in a 'single shot' chamber driven by a pneumatic pump
I
Intervention
Laser Doppler velocimetry to measure flow velocity components over a 30 ms period encompassing initial valve impact and rebound
O
Outcome
Flow velocity components, vortex development, and wall shear rates during valve closuresurrogate

In vitro fluid mechanics analysis reveals high peak wall shear rates and vortex formation during tilting disk mechanical heart valve closure, highlighting potential mechanisms for hemolysis and thrombosis.

Cite This Study

Manning et al. (2008) studied this question.

synapsesocial.com/papers/6a855cb035bc0eada8d59894https://doi.org/10.1115/1.2927356
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrating Particle Image Velocimetry and Laser Doppler Velocimetry Measurements of the Regurgitant Flow Field Past Mechanical Heart Valves2001 · 44 citations
  2. 2Vortex Shedding as a Mechanism for Free Emboli Formation in Mechanical Heart Valves1999 · 165 citations
  3. 3Laser Doppler Velocimetry and Flow Visualization Studies in the Regurgitant Leakage Flow Region of Three Mechanical Mitral Valves2001 · 20 citations
  4. 4Adhesion of red cells to foreign surfaces in the presence of flow1974 · 137 citations
  5. 5Human red blood cell hemolysis in a turbulent shear flow: Contribution of Reynolds shear stresses1984 · 247 citations