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September 17, 2008Journal of Biomechanical Engineering

Modifying a Tilting Disk Mechanical Heart Valve Design to Improve Closing Dynamics

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Why the study?

Does a modified tilting disk valve with a dynamic liquid core reduce cavitation energy compared to a standard valve in an in vitro simulation?

Population

In vitro simulation chamber testing mechanical heart valves in the mitral position

Comparison

Modified tilting disk valve with a 'dynamic… vs Normal/unaltered tilting disk valve with a…

Design

Preclinical

Authors

LHLuke H. HerbertsonSDSteven DeutschKMKeefe B. Manning

Discussion

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Overview

Hypothesis-generating for reduced hemolysis with modified mechanical valves; leaves open in vivo translation and clinical relevance.

Structured PICO

Does a modified tilting disk valve with a dynamic liquid core reduce cavitation energy compared to a standard valve in an in vitro simulation?

P
Population
In vitro simulation chamber testing mechanical heart valves in the mitral position
I
Intervention
Modified tilting disk valve with a 'dynamic liquid core' Delrin occluder
C
Comparator
Normal/unaltered tilting disk valve with a standard Delrin occluder
O
Outcome
Cavitation energy (detected as high-frequency pressure transients with a hydrophone) under physiologic (2500 mm Hg/s) and elevated (4500 mm Hg/s) closing conditionssurrogate

A novel dynamic liquid core modification to tilting disk mechanical valves significantly reduces cavitation intensity in vitro, suggesting a potential mechanism to reduce closure-induced hemolysis.

Cite This Study

Herbertson et al. (2008) studied this question.

synapsesocial.com/papers/6a855cb035bc0eada8d59893https://doi.org/10.1115/1.2978987
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Relative Blood Damage in the Three Phases of a Prosthetic Heart Valve Flow Cycle1993 · 17 citations