Cardiac Damage Staging Classification in Asymptomatic Moderate or Severe Primary Mitral Regurgitation

Figures

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  Figure 1. Analysis of mortality and hospitalization as per the cardiac damage staging classification. Kaplan-Meier curves of all-cause mortality (a) and the composite of cardiovascular mortality or hospital admission (b) as per the staging classification. Percentage (%) is mortality rates after 10 years of follow-up. The number at the bottom of the graphs is numbers of patients at risk at each time interval. Abbreviations: CI, confidence interval; HR, hazard ratio.

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  Figure 2. Analysis of mortality and hospitalization as per the cardiac damage staging classification in the subsets of patients with moderate vs. severe primary MR. All-cause mortality (a and c) and the composite of cardiovascular mortality or hospital admission (b and d) as per the staging classification in the subsets of patients with moderate MR (n = 187; panels a and b) and patients with severe MR (n = 151; panels c and d). Abbreviations as in Figure 1. MR, mitral regurgitation.

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  Figure 3. Association between cardiac damage staging classification and risk of mortality. The figure shows the cardiac damage staging classification and the prevalence of cardiac damage stages in the study population (a), and the association with increased risk of all-cause mortality for each increment in the stage of cardiac damage (b) by adjusted Cox curves. ∗HR is the hazard ratio for all-cause mortality, per one-stage increase, obtained by Cox multivariable analysis adjusted for EuroSCORE II, hypertension, history of stroke, MR severity, mitral valve intervention as a time-dependent variable, and stage of damage as a continuous variable expressed by one-step increase. †HR is the hazard ratio for all-cause mortality, for stage ≥3, obtained by Cox multivariable analysis adjusted for the same variables. Abbreviations as in Figures 1 and 2. LA, left atrial; LV, left ventricular; LVEF, LV ejection fraction; RV, right ventricular.