Key result
This review outlines the mechanisms, pharmacological options, predictors of deterioration, and treatment strategies for patients with left-sided valvular heart disease.
Why the study?
Left-sided valvular heart disease significantly affects life and lifestyle, medical therapy only palliates severe disease, and symptoms or haemodynamic sequelae markedly truncate life expectancy.
Provides a comprehensive review of the mechanisms, medical therapy, and interventional options for managing left-sided valvular heart disease.
Answers are grounded in this paper and cite their sources.
Consolidates management strategies for left-sided valvular disease; leaves open the need for prospective trials on predictors and timing.
Left sided valvular heart disease poses major impact on life and lifestyle. Medical therapy merely palliates chronic severe valve disease and once symptoms or haemodynamic sequelae appear, life expectancy is markedly truncated. In this article, we review the mechanisms of valve pathology, latest evidence in the quest for pharmacological options, means by which to predict deterioration, and standard and novel treatment options.
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McConkey et al. (2018) conducted a review in Left sided valvular heart disease. This review outlines the mechanisms, pharmacological options, predictors of deterioration, and treatment strategies for patients with left-sided valvular heart disease.
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