Key result
Mitral valve repair with a personalized ring resulted in a greater mitral valve area and preserved mitral annular sphincter function compared to the Physio II ring.
Why the study?
Mitral annular size, shape, and motion vary substantially among patients, meaning commercially available rings may not be suitable for every individual.
Cohort (n=127)
No
Answers are grounded in this paper and cite their sources.
Personalized rings may yield larger mitral valve area and preserved function; hypothesis-generating pending randomized trials.
BACKGROUND: Mitral valve repair with the use of an annuloplasty ring is the procedure of choice in patients with significant mitral regurgitation (MR) due to floppy mitral valve (FMV)/mitral valve prolapse (MVP). The mitral annular size, shape and motion may vary substantially among patients and thus, commercially available rings may not be suitable for each individual patient. METHODS: A "personalized ring" (PR) was easily constructed in the operating room using a Dacron sheet and titanium ligating clips to custom fit to each individual mitral annulus shape and size. There were 127 patients with severe MR due to FMV/MVP that underwent mitral valve repair surgery; 58 patients received a PR and 69 patients received a commercial Carpentier-Edwards Physio II ring. The patient records were retrospectively analysed. RESULTS: There were no surgical deaths. In-hospital length-of-stay and blood transfusions were not statistically different between the two groups. Mitral valve area was greater (p < 0.05) in the PR group (3.78 ± 0.22) compared to the Physio II ring group (3.13 ± 0.21). Mitral annular area changed from systole to diastole by 14.35% ± 3.28% in the PR group and did not change in the Physio II ring group (p < 0.05). Systolic anterior motion (SAM) of the mitral valve occurred in 2 patients with the Physio II ring and no patients with the PR. Up to 8 years follow-up, all patients in both groups were alive with NYHA functional class I-II symptoms and mild or less MR. CONCLUSIONS: The PR is suitable for all patients with significant MR due to FMV/MVP who require MV repair. The precise fit of the PR to the mitral annulus better preserves valve area and sphincter function of the mitral annulus, prevents SAM and provides excellent short and long-term results.
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Pitsis et al. (2019) conducted a cohort in Severe mitral regurgitation due to floppy mitral valve/mitral valve prolapse (n=127). Personalized ring vs. Carpentier-Edwards Physio II ring was evaluated on Mitral valve area (p=<0.05). Mitral valve repair with a personalized ring resulted in a greater mitral valve area and preserved mitral annular sphincter function compared to the Physio II ring.
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