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January 1, 2002Age and AgeingOpen Access

beta-blockers in left ventricular systolic dysfunction--from evidence to practice

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Key result

Although evidence shows beta-blockers reduce mortality by about 36% when added to ACE inhibitors in heart failure, clinicians remain reluctant to prescribe them, especially in older patients.

Why the study?

Do beta-blockers reduce mortality in older patients with heart failure when added to ACE inhibitors?

Population

Patients with heart failure, particularly older patients

Design

Review

Authors

SBSyamasis BandyopadhyayApollo Hospitals

Discussion

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Overview

May reduce prescribing reluctance in older HF patients on ACE inhibitors; leaves real-world adoption barriers open.

Structured PICO

Do beta-blockers reduce mortality in older patients with heart failure when added to ACE inhibitors?

P
Population
Patients with heart failure, particularly older patients
I
Intervention
Beta-blockers added to angiotensin-converting enzyme inhibitors
O
Outcome
Mortalityhard clinical

This review highlights the overwhelming evidence for a 36% mortality reduction with beta-blockers in heart failure, aiming to overcome clinician reluctance to prescribe them, especially in older patients.

Cite This Study

Syamasis Bandyopadhyay (2002) conducted a review in Heart failure. Beta-blockers was evaluated. Although evidence shows beta-blockers reduce mortality by about 36% when added to ACE inhibitors in heart failure, clinicians remain reluctant to prescribe them, especially in older patients.

synapsesocial.com/papers/6a13db1a40803be22f89133bhttps://doi.org/10.1093/ageing/31.1.23
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1North of England evidence based development project: guideline for angiotensin converting enzyme inhibitors in primary care management of adults with symptomatic heart failure1998 · 87 citations
  2. 2Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure1991 · 8,072 citations
  3. 3Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials1995 · 1,539 citations
  4. 4Double-Blind, Placebo-Controlled Study of the Long-term Efficacy of Carvedilol in Patients With Severe Chronic Heart Failure1995 · 376 citations
  5. 5Management of patients with heart failure: are internists as good as cardiologists?2001 · 10 citations