Key result
While ivabradine is associated with an increased incidence of new-onset atrial fibrillation, emerging evidence suggests it may also have a role in rate control and maintenance of sinus rhythm.
Why the study?
Data are contradictory regarding whether ivabradine controls heart rate and maintains sinus rhythm in AF or conversely increases the incidence of new-onset AF.
Does ivabradine increase the risk of new-onset atrial fibrillation or have a therapeutic role in its management?
Does ivabradine increase the risk of new-onset atrial fibrillation or have a therapeutic role in its management?
This review highlights the conflicting evidence surrounding ivabradine, noting both its potential to induce new-onset AF and its experimental use for AF rate control and rhythm maintenance.
Warrants AF monitoring with ivabradine; leaves open its possible role in AF rate/rhythm control pending prospective trials.
). It has been approved by the European Medicines Agency and the US Food and Drug Administration for patients with stable angina and heart failure (HF). AF is a common issue especially in ischaemic heart disease and HF patients. In contrast to experimental findings and a limited number of clinical trials that demonstrate the emerging role of ivabradine for heart rate control in AF or maintenance of sinus rhythm, there is accumulating contradictory data indicating that there is, in fact, an increased incidence of new-onset AF among people who are taking ivabradine in clinical practice. This article reviews the most recent evidence highlighting the diversity of data in relation to the use of ivabradine and the onset of AF and whether it has a legitimate role in AF treatment and the maintenance of sinus rhythm.
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Abdelnabi et al. (2020) conducted a review in Atrial Fibrillation. Ivabradine was evaluated. While ivabradine is associated with an increased incidence of new-onset atrial fibrillation, emerging evidence suggests it may also have a role in rate control and maintenance of sinus rhythm.
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