Key result
Arthritis-mediated systemic inflammation fails to cause or modify aortic constriction-induced heart failure in mice.
Why the study?
Patients with rheumatoid arthritis have increased risk of heart failure, but the underlying mechanisms and cardiac prerequisites explaining this association remain unresolved.
Does delayed-type hypersensitivity arthritis modify the development of heart failure caused by aortic constriction in mice?
Population
Mice subjected to HF by ascending aorta constriction or sham surgery
Comparison
DTHA induction vs no DTHA
Design
Animal experimental study with supplemental clinical biomarker comparison
Follow-up
Six weeks after surgery
Authors
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Does not implicate DTHA inflammation in murine HF; leaves open prerequisites for RA-induced cardiac dysfunction.
Does delayed-type hypersensitivity arthritis modify the development of heart failure caused by aortic constriction in mice?
DTHA-mediated systemic inflammation did not cause or modify heart failure caused by aortic constriction in mice, suggesting other prerequisites are needed for RA-induced cardiac dysfunction.
Tønnessen et al. (2022) studied Heart failure and rheumatoid arthritis. Delayed-type hypersensitivity arthritis (DTHA) vs. Sham operation / no DTHA was evaluated on Cardiac dysfunction and heart failure development. Delayed-type hypersensitivity arthritis-mediated systemic inflammation did not cause or modify heart failure caused by aortic constriction in mice.
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