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May 25, 2026Frontiers in ImmunologyOpen Access

The interplay between neuroinflammation and endothelial dysfunction in cerebral small vessel disease

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Authors

CJCong JinYZYin Zhao

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Overview

Review synthesizes evidence on endothelial dysfunction and neuroinflammation in cerebral small vessel disease, suggesting therapeutic strategies.

Key Points

  • This review aims to elucidate the complex relationship between neuroinflammation and endothelial dysfunction in cerebral small vessel disease.
  • Review of current human and experimental evidence on the interrelationship of endothelial dysfunction and neuroinflammation.
  • Synthesis of available literature to propose a working framework for understanding CSVD pathology.
  • Evaluation of therapeutic strategies targeting endothelial dysfunction and neuroinflammation pathways.
  • Endothelial dysfunction and neuroinflammation are closely linked, with vascular risk factors exacerbating both.
  • Pericytes, astrocytes, and microglia amplify barrier injuries and inflammation, promoting further dysfunction.
  • Chronic neuroinflammation may sustain endothelial dysfunction and alter response to future inflammatory events.

Cite This Study

Jin et al. (2026) studied this question.

synapsesocial.com/papers/6a13e67d0e02ee3982d316b2https://doi.org/10.3389/fimmu.2026.1809556
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