Review discusses endothelial dysfunction's role in cerebral small vessel disease, highlighting targeted therapeutic strategies and implications.
Key Points
This review analyzes the role of endothelial dysfunction in cerebral small vessel disease and explores potential therapeutic strategies.
Systematic synthesis of current understanding of cerebrovascular health and disease mechanisms.
Evaluation of therapeutic strategies targeting endothelial function, including pharmacological and innovative approaches.
Assessment of biomarkers and neuroimaging techniques related to endothelial dysfunction in cerebral small vessel disease.
Endothelial dysfunction significantly contributes to various pathological processes in cerebral small vessel disease, including impaired vasoreactivity and neurovascular unit disintegration.
Promising therapeutic strategies aim to restore endothelial function, yet translational challenges remain in clinical applications and biomarker identification.
Emerging methods for assessing endothelial dysfunction may enhance early diagnosis and therapeutic targeting for cerebrovascular complications.