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July 16, 2025Frontiers in Aging NeuroscienceOpen Access

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

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Authors

YYYanrong YangHCHua ChenQLQibing Liu

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Overview

Research uncovers endothelial cell roles in vascular dementia, highlighting potential treatments through neurovascular coupling and blood-brain barrier integrity.

Key Points

  • Vascular dementia is the second most prevalent dementia subtype, next to Alzheimer’s disease.
  • Cerebrovascular endothelial cells play dual roles in maintaining blood-brain barrier integrity and neurovascular function.
  • Neuroinflammation and oxidative stress are crucial in the pathophysiological progression of vascular dementia.
  • The study proposes multi-modal therapeutic strategies focused on endothelial cells to improve cognitive outcomes in vascular dementia.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/689a02c3e6551bb0af8ccb87https://doi.org/10.3389/fnagi.2025.1623050
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular cognitive impairment and dementia: current understanding and future directions2026
  2. 2Mechanistic Insights and Translational Therapeutics of Neurovascular Unit Dysregulation in Vascular Cognitive Impairment2025
  3. 3Vascular Dementia: From Pathophysiology to Therapeutic Frontiers2025 · 30 citations
  4. 4Unifying Vascular Injury and Neurodegeneration: A Mechanistic Continuum in Cerebral Small Vessel Disease and Dementia2025 · 14 citations
  5. 5Identifying targets at the blood-brain barrier for treating vascular cognitive impairment and dementia2026