This review discusses lipid metabolism disruption affecting neurovascular unit function in Alzheimer's and vascular dementia, suggesting new therapeutic avenues.
Key Points
To explore the links between lipid metabolism dysregulation and neurovascular unit dysfunction in Alzheimer’s disease and vascular dementia.
Comprehensive literature review on neurovascular unit composition and function.
Analysis of lipid metabolism's impact on neuroinflammation and blood-brain barrier integrity.
Examination of both human and preclinical animal models to identify pathophysiological differences.
NVU dysfunction is a key early event in Alzheimer’s and vascular dementia.
Disrupted lipid homeostasis leads to increased oxidative stress and impaired amyloid-β clearance.
Controversy exists around the effects of apolipoprotein E ε4 allele on neurodegeneration.