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September 10, 2025Journal of Integrative NeuroscienceOpen Access

Mechanistic Insights and Translational Therapeutics of Neurovascular Unit Dysregulation in Vascular Cognitive Impairment

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Authors

LLL. LinYHYiling HuangJXJiayi Xu

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Overview

Review highlights mechanisms of vascular cognitive impairment and neurovascular unit dysfunction, suggesting proactive management may mitigate dementia risks.

Key Points

  • Endothelial dysfunction initiates a vicious cycle of neurovascular unit dysregulation that worsens cognitive impairment.
  • Vascular cognitive impairment spans conditions from mild cognitive impairment to dementia, impacting healthcare systems seriously.
  • Emerging evidence emphasizes the neurovascular unit as critical for regulating nutrient transport and neuroinflammatory signaling.
  • Preventive strategies targeting vascular risk factors could potentially decrease the progression from vascular injury to dementia.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68c198b59b7b07f3a061a265https://doi.org/10.31083/jin40091
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Also Consider

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  1. 1Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia2025
  2. 2Vascular cognitive impairment and dementia: current understanding and future directions2026
  3. 3Pulse of Cognition: Investigating Neurovascular Coupling's Role in Cognition and Therapeutic Promise for Alzheimer’s, Parkinson’s, and Dementia2025
  4. 4Unifying Vascular Injury and Neurodegeneration: A Mechanistic Continuum in Cerebral Small Vessel Disease and Dementia2025 · 14 citations
  5. 5Dysregulated Lipid Metabolism and Neurovascular Unit Dysfunction: Novel Mechanisms Linking Alzheimer’s Disease and Vascular Dementia2026 · 1 citations