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September 10, 2025European Journal of Neuroscience

Unifying Vascular Injury and Neurodegeneration: A Mechanistic Continuum in Cerebral Small Vessel Disease and Dementia

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Authors

CJChengbin JinSBSonu Bhaskar

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Overview

This hypothesis-driven review proposes that cerebral small vessel disease amplifies neurodegeneration, suggesting a novel approach to dementia prevention.

Key Points

  • Cerebral small vessel disease significantly contributes to cognitive impairment and dementia.
  • The proposed continuum reveals how vascular pathology can initiate and accelerate neurodegeneration.
  • Key mechanisms includeBBB breakdown and chronic cerebral hypoperfusion, leading to cognitive decline.
  • Novel diagnostic and therapeutic strategies may enhance precision medicine approaches for dementia.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/68c193e99b7b07f3a0617e83https://doi.org/10.1111/ejn.70246
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanistic Insights and Translational Therapeutics of Neurovascular Unit Dysregulation in Vascular Cognitive Impairment2025
  2. 2The interplay between neuroinflammation and endothelial dysfunction in cerebral small vessel disease2026 · 2 citations
  3. 3Vascular cognitive impairment and dementia: current understanding and future directions2026
  4. 4Progress in pathological mechanisms and targeted strategies for endothelial dysfunction-mediated cerebral small vessel disease2026
  5. 5Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia2025