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May 25, 2026Frontiers in NutritionOpen Access

Functional processing enhances hepatic targeting: the OAT2/MRP2 mechanism of vinegar-processed Cyperi Rhizoma

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Authors

GXGui XuYCYuehua ChenSJShiru Jiang

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Overview

Randomized trial investigates vinegar-processed Cyperi Rhizoma's effects on liver uptake, suggesting its potential as a protective functional food.

Key Points

  • The study aims to explore the molecular mechanism by which vinegar processing enhances the hepatic targeting of Cyperi Rhizoma.
  • Integrated in silico docking with in vitro experiments
  • Used HS-GC–MS for chemical analysis of vinegar-processed CR
  • Evaluated hepatic uptake in HepaRG cells using UPLC-QqQ-MS
  • UPLC-QqQ-MS showed higher intracellular accumulation of bioactive components from vinegar-processed CR compared to raw CR (p<0.05)
  • Molecular docking indicated high affinity of cyperotundone for hepatic transporters
  • Ligand fishing assays confirmed strong binding with OAT2 and inhibition of MRP2

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a13e67d0e02ee3982d316f5https://doi.org/10.3389/fnut.2026.1821870
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